Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Baar, MP; Brandt, RMC; Putavet, DA; Klein, JDD; Derks, KWJ; Bourgeois, BRM; Stryeck, S; Rijksen, Y; van Willigenburg, H; Feijtel, DA; van der Pluijm, I; Essers, J; van Cappellen, WA; van IJcken, WF; Houtsmuller, AB; Pothof, J; de Bruin, RWF; Madl, T; Hoeijmakers, JHJ; Campisi, J; de Keizer, PLJ.
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell. 2017; 169(1):132-147 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Madl Tobias
Stryeck Sarah
Altmetrics:

Dimensions Citations:

Plum Analytics:
Number of Figures: 7
| | | | | | |
Abstract:
The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function, and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can also be restored. Here, we identify FOXO4 as a pivot in senescent cell viability. We designed a FOXO4 peptide that perturbs the FOXO4 interaction with p53. In senescent cells, this selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis. Under conditions where it was well tolerated in vivo, this FOXO4 peptide neutralized doxorubicin-induced chemotoxicity. Moreover, it restored fitness, fur density, and renal function in both fast aging XpdTTD/TTD and naturally aged mice. Thus, therapeutic targeting of senescent cells is feasible under conditions where loss of health has already occurred, and in doing so tissue homeostasis can effectively be restored. Copyright © 2017 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aging - drug effects
Aging - pathology
Animals -
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - adverse effects
Antibiotics, Antineoplastic - pharmacology
Apoptosis -
Cell Line -
Cell Survival -
Cell-Penetrating Peptides - pharmacology
Cellular Senescence - drug effects
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Doxorubicin - pharmacology
Female -
Fibroblasts - cytology
Forkhead Transcription Factors - chemistry
Forkhead Transcription Factors - metabolism
Humans -
Inclusion Bodies - drug effects
Inclusion Bodies - metabolism
Inclusion Bodies - pathology
Kidney - drug effects
Kidney - physiology
Liver - drug effects
Liver - physiology
Male -
Mice -
Trichothiodystrophy Syndromes - drug therapy
Tumor Suppressor Protein p53 - metabolism

© Meduni Graz Impressum