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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Löffler, T; Schweinzer, C; Flunkert, S; Sántha, M; Windisch, M; Steyrer, E; Hutter-Paier, B.
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice.
Mol Cell Neurosci. 2016; 74(2):34-41
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Löffler Tina
Schweinzer Cornelia Katrin
Steyrer Ernst

Dimensions Citations:

Plum Analytics:
Processing of the amyloid precursor protein (APP) and amyloid beta (Aβ) has been for decades in the center of Alzheimer's disease (AD) research. Beside many other variables, lipids, especially cholesterol and its derivatives, are discussed to contribute to AD pathogenesis. Several studies show that cholesterol affects APP metabolism. Also the converse mechanism, the direct influence of Aβ on cholesterol metabolism, has been described. To further investigate this crosstalk between cholesterol- and APP metabolism, a high-fat feeding study was conducted with animals overexpressing human APPSL and/or human ApoB-100. The impact of diet and genotype on cerebral cholesterol metabolism and content as well as spatial learning and memory was examined. While behavioral performance was not influenced by this high fat diet (HFD), reduction of cortical free cholesterol levels and mRNA expression patterns under normal diet and HFD conditions in human APPSL overexpressing mice argue for an important role of APP in cerebral lipid metabolism. From our results we conclude that increased APP metabolism in ApoBxAPP and APPSL mice induces mechanisms to reduce free cholesterol levels. Copyright © 2016. Published by Elsevier Inc.
Find related publications in this database (using NLM MeSH Indexing)
Alzheimer Disease - blood
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Animals -
Apolipoprotein B-100 - genetics
Apolipoprotein B-100 - metabolism
Cerebral Cortex - metabolism
Cholesterol - blood
Cholesterol - metabolism
Diet, High-Fat - adverse effects
Dietary Fats - metabolism
Female -
Genotype -
Homeostasis -
Humans -
Male -
Maze Learning -
Mice -
Mice, Inbred C57BL -

Find related publications in this database (Keywords)
Alzheimer's disease
A beta
Amyloid precursor protein overexpression
Mouse model
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