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Okbay, A; Baselmans, BM; De Neve, JE; Turley, P; Nivard, MG; Fontana, MA; Meddens, SF; Linnér, RK; Rietveld, CA; Derringer, J; Gratten, J; Lee, JJ; Liu, JZ; de Vlaming, R; Ahluwalia, TS; Buchwald, J; Cavadino, A; Frazier-Wood, AC; Furlotte, NA; Garfield, V; Geisel, MH; Gonzalez, JR; Haitjema, S; Karlsson, R; van der Laan, SW; Ladwig, KH; Lahti, J; van der Lee, SJ; Lind, PA; Liu, T; Matteson, L; Mihailov, E; Miller, MB; Minica, CC; Nolte, IM; Mook-Kanamori, D; van der Most, PJ; Oldmeadow, C; Qian, Y; Raitakari, O; Rawal, R; Realo, A; Rueedi, R; Schmidt, B; Smith, AV; Stergiakouli, E; Tanaka, T; Taylor, K; Wedenoja, J; Wellmann, J; Westra, HJ; Willems, SM; Zhao, W; LifeLines Cohort Study; Amin, N; Bakshi, A; Boyle, PA; Cherney, S; Cox, SR; Davies, G; Davis, OS; Ding, J; Direk, N; Eibich, P; Emeny, RT; Fatemifar, G; Faul, JD; Ferrucci, L; Forstner, A; Gieger, C; Gupta, R; Harris, TB; Harris, JM; Holliday, EG; Hottenga, JJ; De Jager, PL; Kaakinen, MA; Kajantie, E; Karhunen, V; Kolcic, I; Kumari, M; Launer, LJ; Franke, L; Li-Gao, R; Koini, M; Loukola, A; Marques-Vidal, P; Montgomery, GW; Mosing, MA; Paternoster, L; Pattie, A; Petrovic, KE; Pulkki-Råback, L; Quaye, L; Räikkönen, K; Rudan, I; Scott, RJ; Smith, JA; Sutin, AR; Trzaskowski, M; Vinkhuyzen, AE; Yu, L; Zabaneh, D; Attia, JR; Bennett, DA; Berger, K; Bertram, L; Boomsma, DI; Snieder, H; Chang, SC; Cucca, F; Deary, IJ; van Duijn, CM; Eriksson, JG; Bültmann, U; de Geus, EJ; Groenen, PJ; Gudnason, V; Hansen, T; Hartman, CA; Haworth, CM; Hayward, C; Heath, AC; Hinds, DA; Hyppönen, E; Iacono, WG; Järvelin, MR; Jöckel, KH; Kaprio, J; Kardia, SL; Keltikangas-Järvinen, L; Kraft, P; Kubzansky, LD; Lehtimäki, T; Magnusson, PK; Martin, NG; McGue, M; Metspalu, A; Mills, M; de Mutsert, R; Oldehinkel, AJ; Pasterkamp, G; Pedersen, NL; Plomin, R; Polasek, O; Power, C; Rich, SS; Rosendaal, FR; den Ruijter, HM; Schlessinger, D; Schmidt, H; Svento, R; Schmidt, R; Alizadeh, BZ; Sørensen, TI; Spector, TD; Steptoe, A; Terracciano, A; Thurik, AR; Timpson, NJ; Tiemeier, H; Uitterlinden, AG; Vollenweider, P; Wagner, GG; Weir, DR; Yang, J; Conley, DC; Smith, GD; Hofman, A; Johannesson, M; Laibson, DI; Medland, SE; Meyer, MN; Pickrell, JK; Esko, T; Krueger, RF; Beauchamp, JP; Koellinger, PD; Benjamin, DJ; Bartels, M; Cesarini, D.
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Nat Genet. 2016; 48(6):624-633 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Koini Marisa
Petrovic Katja Elisabeth
Schmidt Helena
Schmidt Reinhold
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Number of Figures: 4
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Abstract:
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

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