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SHR Neuro Krebs Kardio Lipid

Alfakry, H; Malle, E; Koyani, CN; Pussinen, PJ; Sorsa, T.
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease.
Innate Immun. 2016; 22(1):85-99 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Koyani Chintan Navinchandra
Malle Ernst

Dimensions Citations:

Plum Analytics:
Cardiovascular diseases are chronic inflammatory diseases that affect a large segment of society. Coronary heart disease (CHD), the most common cardiovascular disease, progresses over several years and affects millions of people worldwide. Chronic infections may contribute to the systemic inflammation and enhance the risk for CHD. Periodontitis is one of the most common chronic infections that affects up to 50% of the adult population. Under inflammatory conditions the activation of endogenous degradation pathways mediated by immune responses leads to the release of destructive cellular molecules from both resident and immigrant cells. Matrix metalloproteinases (MMPs) and their regulators can activate each other and play an important role in immune response via degrading extracellular matrix components and modulating cytokines and chemokines. The action of MMPs is required for immigrant cell recruitment at the site of inflammation. Stimulated neutrophils represent the major pathogen-fighting immune cells that upregulate expression of several proteinases and oxidative enzymes, which can degrade extracellular matrix components (e.g. MMP-8, MMP-9 and neutrophil elastase). The activity of MMPs is regulated by endogenous inhibitors and/or candidate MMPs (e.g. MMP-7). The balance between MMPs and their inhibitors is thought to mirror the proteolytic burden. Thus, neutrophil-derived biomarkers, including myeloperoxidase, may activate proteolytic destructive cascades that are involved in subsequent immune-pathological events associated with both periodontitis and CHD. Here, we review the existing studies on the contribution of MMPs and their regulators to the infection-related pathology. Also, we discuss the possible proteolytic involvement and role of neutrophil-derived enzymes as an etiological link between chronic periodontitis and CHD. © The Author(s) 2015.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Animals -
Chronic Disease -
Chronic Periodontitis - complications
Chronic Periodontitis - immunology
Coronary Disease - etiology
Coronary Disease - immunology
Humans -
Infection - complications
Infection - immunology
Matrix Metalloproteinases - metabolism
Neutrophil Activation -
Neutrophils - physiology
Proteolysis -
Risk -

Find related publications in this database (Keywords)
Aggregatibacter actinomycetemcomitans
cardiovascular disease
coronary artery disease
gingival crevicular fluids
hypochlorous acid
matrix metalloproteinases
oral infections
periodontal diseases
Porphyromonas gingivalis
tissue inhibitor of matrix metalloproteinases
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