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SHR Neuro Krebs Kardio Lipid

Büttner, S; Broeskamp, F; Sommer, C; Markaki, M; Habernig, L; Alavian-Ghavanini, A; Carmona-Gutierrez, D; Eisenberg, T; Michael, E; Kroemer, G; Tavernarakis, N; Sigrist, SJ; Madeo, F.
Spermidine protects against α-synuclein neurotoxicity.
Cell Cycle. 2014; 13(24):3903-3908 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Alavian Ghavanini Ali
Sommer Constanze
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Number of Figures: 2
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Abstract:
As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, two established model systems for PD pathology. In the fruit fly, simple feeding with spermidine inhibited loss of climbing activity and early organismal death upon heterologous expression of human α-synuclein, which is thought to be the principal toxic trigger of PD. In this line, administration of spermidine rescued α-synuclein-induced loss of dopaminergic neurons, a hallmark of PD, in nematodes. Alleviation of PD-related neurodegeneration by spermidine was accompanied by induction of autophagy, suggesting that this cytoprotective process may be responsible for the beneficial effects of spermidine administration.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Autophagy - drug effects
Caenorhabditis elegans - metabolism
Disease Models, Animal -
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - metabolism
Drosophila melanogaster - metabolism
Humans -
Manganese - toxicity
Motor Activity - drug effects
Parkinson Disease - metabolism
Parkinson Disease - pathology
Protective Agents - pharmacology
Spermidine - pharmacology
alpha-Synuclein - genetics
alpha-Synuclein - metabolism

Find related publications in this database (Keywords)
autophagy
aging
-synuclein
dopaminergic neuron loss
motor dysfunction
neurodegeneration
Parkinson's disease
Spermidine
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