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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Rossmann, C; Hammer, A; Koyani, CN; Kovacevic, A; Siwetz, M; Desoye, G; Poehlmann, TG; Markert, UR; Huppertz, B; Sattler, W; Malle, E.
Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells.
Placenta. 2014; 35(8):661-664 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Desoye Gernot
Hammer Astrid
Huppertz Berthold
Kovacevic Alenka
Koyani Chintan Navinchandra
Malle Ernst
Rossmann Christine Renate
Sattler Wolfgang
Siwetz Monika
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Abstract:
Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast preparations of human first trimester and term placenta. SAA4 mRNA was expressed in non-stimulated and cytokine-treated AC1-M59/Jeg-3 cells. In purified trophoblast cells SAA4 mRNA expression was upregulated at weeks 10 and 12 of pregnancy. Western-blot and immunohistochemical staining of first trimester placental tissue revealed pronounced SAA4 expression in invasive trophoblast cells indicating a potential role of SAA4 during invasion. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Find related publications in this database (Keywords)
SAA4
Placenta
Invasion
Cytokine
Outgrowing extravillous trophoblast
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