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SHR Neuro Krebs Kardio Lipid

Marsche, G; Heller, R; Fauler, G; Kovacevic, A; Nuszkowski, A; Graier, W; Sattler, W; Malle, E.
2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis.
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Autor/innen der Med Uni Graz:
Fauler Günter
Graier Wolfgang
Malle Ernst
Marsche Gunther
Sattler Wolfgang

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Plum Analytics:
OBJECTIVE: Myeloperoxidase, a heme enzyme that is present and active in human atherosclerotic lesions, provides a source for the generation of proinflammatory chlorinated reactants contributing to endothelial dysfunction. Modification of high-density lipoprotein (HDL) by hypochlorous acid/hypochlorite (HOCl/OCl-) [correction]-generated in vivo by the myeloperoxidase-hydrogen peroxide-chloride system of activated phagocytes-forms a proatherogenic lipoprotein particle that binds to and is internalized by endothelial cells. METHODS AND RESULTS: Here we show that HDL, modified with physiologically relevant HOCl concentrations, attenuates the expression and activity of vasculoprotective endothelial nitric oxide synthase. HOCl-HDL promotes dislocalization of endothelial nitric oxide synthase from the plasma membrane and perinuclear location of human umbilical venous endothelial cells. We could identify 2-chlorohexadecanal as the active component mediating this inhibitory activity. This chlorinated fatty aldehyde is formed during HOCl-mediated oxidative cleavage of HDL-associated plasmalogen. CONCLUSIONS: 2-Chlorohexadecanal, produced by the myeloperoxidase-hydrogen peroxide-chloride system of activated phagocytes may act as a mediator of vascular injury associated with ischemia-reperfusion injury, glomerulosclerosis, and atherosclerosis.
Find related publications in this database (using NLM MeSH Indexing)
Aldehydes - metabolism
Cell Line - metabolism
Endothelial Cells - enzymology
Endothelium, Vascular - enzymology
Enzyme Activation - drug effects
Humans - drug effects
Hypochlorous Acid - metabolism
Lipoproteins, HDL - metabolism
Nitric Oxide - antagonists and inhibitors
Nitric Oxide Synthase - antagonists and inhibitors
Nitric Oxide Synthase Type III - antagonists and inhibitors
Plasmalogens - metabolism
Umbilical Veins - cytology

Find related publications in this database (Keywords)
2-chlorinated fatty aldehyde
modified lipids
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