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SHR Neuro Krebs Kardio Lipid

Doddapattar, P; Radović, B; Patankar, JV; Obrowsky, S; Jandl, K; Nusshold, C; Kolb, D; Vujić, N; Doshi, L; Chandak, PG; Goeritzer, M; Ahammer, H; Hoefler, G; Sattler, W; Kratky, D.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Mol Nutr Food Res. 2013; 57(10):1718-1728 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Ahammer Helmut
Chandak Prakash Gopal Das
Doddapattar Prakash
Doshi Lalitkumar Subhash
Göritzer Madeleine
Hoefler Gerald
Jandl Katharina
Kolb-Lenz Dagmar
Kratky Dagmar
Nusshold Christoph
Obrowsky Sascha
Patankar Jay Vasant
Radovic Branislav
Sattler Wolfgang
Vujic Nemanja
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Number of Figures: 7
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Abstract:
Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. Based on its favorable biological properties, we investigated whether XN attenuates atherosclerosis in western-type diet-fed apolipoprotein-E-deficient (ApoE⁻/⁻) mice. XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic lesion area, and attenuated plasma concentrations of the proinflammatory cytokine monocyte chemoattractant protein 1. Decreased hepatic triglyceride and cholesterol content, activation of AMP-activated protein kinase, phosphorylation and inactivation of acetyl-CoA carboxylase, and reduced expression levels of mature sterol regulatory element-binding protein (SREBP)-2 and SREBP-1c mRNA indicate reduced lipogenesis in the liver of XN-fed ApoE⁻/⁻ mice. Concomitant induction of hepatic mRNA expression of carnitine palmitoyltransferase-1a in ApoE⁻/⁻ mice-administered XN suggests increased fatty acid beta-oxidation. Fecal cholesterol concentrations were also markedly increased in XN-fed ApoE⁻/⁻ mice compared with mice fed western-type diet alone. The atheroprotective effects of XN might be attributed to combined beneficial effects on plasma cholesterol and monocyte chemoattractant protein 1 concentrations and hepatic lipid metabolism via activation of AMP-activated protein kinase. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Find related publications in this database (using NLM MeSH Indexing)
AMP-Activated Protein Kinases - metabolism
Acetyl-CoA Carboxylase - antagonists & inhibitors
Animals -
Apolipoproteins E - blood
Carnitine O-Palmitoyltransferase - genetics
Chemokine CCL2 - blood
Cholesterol - blood
Fatty Liver - drug therapy
Female -
Flavonoids - pharmacology
Hypercholesterolemia - drug therapy
Lipid Metabolism - drug effects
Lipogenesis - drug effects
Liver - drug effects
Mice -
Phosphorylation -
Plaque, Atherosclerotic - drug therapy
Propiophenones - pharmacology
RNA, Messenger - genetics
Sterol Regulatory Element Binding Protein 1 - genetics
Sterol Regulatory Element Binding Protein 2 - genetics
Triglycerides - blood

Find related publications in this database (Keywords)
AMPK signaling
Atherosclerosis
Inflammation
Lipid metabolism
Xanthohumol
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