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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Radovic, B; Aflaki, E; Kratky, D.
Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.
Biol Chem. 2012; 393(9):1005-1011 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Aflaki Elma
Kratky Dagmar
Radovic Branislav
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Abstract:
Consistent with its central importance in lipid and energy homeostasis, lipolysis occurs in essentially all tissues and cell types, including macrophages. The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes or as energy substrate in mitochondria. This review summarizes the current knowledge concerning the consequences of ATGL deficiency in macrophages with particular emphasis on macrophage (dys)-function, apoptosis, and atherosclerosis.
Find related publications in this database (using NLM MeSH Indexing)
Adipose Tissue - enzymology
Animals -
Atherosclerosis - enzymology
Disease Models, Animal -
Humans -
Inflammation - enzymology
Lipase - immunology
Lipolysis -
Mice -
Triglycerides - immunology

Find related publications in this database (Keywords)
apoptosis
lipolysis
lipotoxicity
macrophages
mouse model
triacylglycerol mobilization
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