Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Freudenberger, P; Schmidt, R; Schmidt, H.
Genetics of age-related white matter lesions from linkage to genome wide association studies.
J Neurol Sci. 2012; 322(1-2):82-86 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Freudenberger Paul
Schmidt Helena
Schmidt Reinhold
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Abstract:
White matter lesions are a frequent phenomenon in the elderly and contribute to the development of disability. The mechanisms underlying these brain lesions are still not fully understood with age and hypertension being the most well established risk factors. The heritability of white matter lesions is consistently high in different populations. Candidate gene studies strongly support the role of genes involved in the renin-angiotensin system, as well as Notch3 signaling. The recent genome wide association study by the CHARGE consortium identified a novel locus on chromosome 17q25 harboring several genes such as TRIM65 and TRIM47 which pinpoint to possible novel mechanisms leading to white matter lesions.
Find related publications in this database (using NLM MeSH Indexing)
Aging - genetics
Blood Pressure - genetics
Chromosomes, Human, Pair 17 - genetics
Genetic Linkage -
Genetic Variation - genetics
Genome-Wide Association Study -
Humans -
Leukoencephalopathies - genetics
Magnetic Resonance Imaging -
Receptors, Notch - genetics
Signal Transduction - genetics

Find related publications in this database (Keywords)
White matter lesions
Leuko-araiosis
Genetics
Polymorphism
Genome wide association study
Risk factor
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