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SHR Neuro Krebs Kardio Lipid

Cheng, YC; Anderson, CD; Bione, S; Keene, K; Maguire, JM; Nalls, M; Rasheed, A; Zeginigg, M; Attia, J; Baker, R; Barlera, S; Biffi, A; Bookman, E; Brott, TG; Brown, RD; Chen, F; Chen, WM; Ciusani, E; Cole, JW; Cortellini, L; Danesh, J; Doheny, K; Ferrucci, L; Grazia Franzosi, M; Frossard, P; Furie, KL; Golledge, J; Hankey, GJ; Hernandez, D; Holliday, EG; Hsu, FC; Jannes, J; Kamal, A; Khan, MS; Kittner, SJ; Koblar, SA; Lewis, M; Lincz, L; Lisa, A; Matarin, M;Moscato, P;Mychaleckyj, JC;Parati, EA;Parolo, S;Pugh, E;Rost, NS;Schallert, M;Schmidt, H;Scott, RJ;Sturm, JW;Yadav, S;Zaidi, M;Boncoraglio, GB;Levi, CR;Meschia, JF;Rosand, J;Sale, M;Saleheen, D;Schmidt, R;Sharma, P;Worrall, B;Mitchell, BD;GARNET Collaborative Research Group;GENEVA Consortium;InternationalStrokeGeneticsConsortium.
Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
Stroke. 2012; 43(4): 980-986. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Schallert Michael
Schmidt Helena
Schmidt Reinhold
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Abstract:
BACKGROUND AND PURPOSE: Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS. METHODS: Meta-analyses of the associations between the 11 MI-associated SNPs and IS were performed using 6865 cases and 11 395 control subjects recruited from 9 studies. SNPs were either genotyped directly or imputed; in a few cases a surrogate SNP in high linkage disequilibrium was chosen. Logistic regression was performed within each study to obtain study-specific âs and standard errors. Meta-analysis was conducted using an inverse variance weighted approach assuming a random effect model. RESULTS: Despite having power to detect odds ratio of 1.09-1.14 for overall IS and 1.20-1.32 for major stroke subtypes, none of the SNPs were significantly associated with overall IS and/or stroke subtypes after adjusting for multiple comparisons. CONCLUSIONS: Our results suggest that the major common loci associated with MI risk do not have effects of similar magnitude on overall IS but do not preclude moderate associations restricted to specific IS subtypes. Disparate mechanisms may be critical in the development of acute ischemic coronary and cerebrovascular events.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Brain Ischemia - genetics
Female -
Genome-Wide Association Study -
Humans -
Linkage Disequilibrium -
Male -
Middle Aged -
Myocardial Infarction - genetics
Polymorphism, Single Nucleotide -
Stroke - genetics

Find related publications in this database (Keywords)
cerebral infarct
genetics
ischemia
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