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SHR Neuro Krebs Kardio Lipid

Sen, A; Gider, P; Cavalieri, M; Freudenberger, P; Farzi, A; Schallert, M; Reichmann, F; Watzinger, N; Zweiker, R; Schmidt, R; Schmidt, H.
Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study.
Neurodegener Dis. 2012; 10(1-4):135-137 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Cavalieri Margherita
Farzi Aitak
Freudenberger Paul
Gider Pierre
Reichmann Florian
Schallert Michael
Schmidt Helena
Schmidt Reinhold
Sen Abhijit
Watzinger Norbert
Zweiker Robert

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Background: Physical activity and cardiorespiratory fitness relate to better cognitive performance. Little is known about the effects of fitness on structural brain abnormalities in the elderly. Objective: Assess the association between maximal oxygen consumption (VO(2)max), white matter lesion (WML) volume and brain parenchymal fraction (BPF) in a large cohort of community-dwelling elderly individuals. Methods: The study population consisted of 715 participants of the Austrian Stroke Prevention Study who underwent brain MRI with semi-automated measurement of WML volume (cm(3)) and automated assessment of BPF (%) by the use of SIENAX. A maximal exercise stress test was done on a bicycle ergometer. VO(2)max was calculated based on maximum and resting heart rate. Results: After adjustment for possible confounders, VO2max was independently associated with WML volume (beta = -0.10; p = 0.02); no significant relationship existed with silent cerebral infarcts and BPF. Associations between VO(2)max and WML load were only significant in men, but not in women. Conclusion: Our findings may have important preventive implications because WMLs are known to be a major determinant of cognitive decline and disability in old age. Copyright (C) 2012 S. Karger AG, Basel
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Aged, 80 and over - epidemiology
Brain - pathology
Cohort Studies -
Female -
Humans -
Image Processing, Computer-Assisted -
Leukoencephalopathies - complications Leukoencephalopathies - pathology
Magnetic Resonance Imaging -
Male -
Middle Aged -
Models, Statistical -
Oxygen Consumption - physiology
Physical Fitness -
Residence Characteristics -
Sex Factors -
Stroke - epidemiology Stroke - pathology Stroke - prevention and control

Find related publications in this database (Keywords)
Physical activity
Cardiorespiratory fitness
Cerebral small-vessel disease
White matter lesions
Exercise ECG
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