Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Cavalieri, M; Schmidt, H; Schmidt, R.
Structural MRI in normal aging and Alzheimer's disease: white and black spots.
Neurodegener Dis. 2012; 10(1-4):253-256
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Cavalieri Margherita
Schmidt Helena
Schmidt Reinhold

Dimensions Citations:

Plum Analytics:
Background: White matter changes (WMC) and microbleeds (MBs) are common in the elderly and in patients with Alzheimer's disease (AD). Objective: To describe the prevalence, anatomical distribution and longitudinal changes of WMC and MBs in normal aging subjects compared to AD patients and to describe current evidence of their effects on the clinical course of AD. Methods: Short literature review. Results: WMC and MBs are more frequent and progress more rapidly in AD patients than in cognitively normal elderly. New MBs occur in up to one quarter of AD cases without any therapeutic intervention. WMC and MBs influence the clinical course of AD. Conclusion: WMC and MBs might represent treatment targets in clinical trials on AD. Copyright (C) 2012 S. Karger AG, Basel
Find related publications in this database (using NLM MeSH Indexing)
Aging - pathology
Alzheimer Disease - complications
Brain - pathology
Humans -
Image Processing, Computer-Assisted -
Magnetic Resonance Imaging -
Nerve Fibers, Myelinated - pathology

Find related publications in this database (Keywords)
Normal aging
Alzheimer's disease
Brain MRI
White matter changes
© Meduni Graz Impressum