Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Bis, JC; Kavousi, M; Franceschini, N; Isaacs, A; Abecasis, GR; Schminke, U; Post, WS; Smith, AV; Cupples, LA; Markus, HS; Schmidt, R; Huffman, JE; Lehtimäki, T; Baumert, J; Münzel, T; Heckbert, SR; Dehghan, A; North, K; Oostra, B; Bevan, S; Stoegerer, EM; Hayward, C; Raitakari, O; Meisinger, C; Schillert, A; Sanna, S; Völzke, H; Cheng, YC; Thorsson, B; Fox, CS; Rice, K; Rivadeneira, F; Nambi, V; Halperin, E; Petrovic, KE; Peltonen, L; Wichmann, HE; Schnabel, RB; Dörr, M; Parsa, A; Aspelund, T; Demissie, S; Kathiresan, S; Reilly, MP; Taylor, K; Uitterlinden, A; Couper, DJ; Sitzer, M; Kähönen, M; Illig, T; Wild, PS; Orru, M; Lüdemann, J; Shuldiner, AR; Eiriksdottir, G; White, CC; Rotter, JI; Hofman, A; Seissler, J; Zeller, T; Usala, G; Ernst, F; Launer, LJ; D'Agostino, RB; O'Leary, DH; Ballantyne, C; Thiery, J; Ziegler, A; Lakatta, EG; Chilukoti, RK; Harris, TB; Wolf, PA; Psaty, BM; Polak, JF; Li, X; Rathmann, W; Uda, M; Boerwinkle, E; Klopp, N; Schmidt, H; Wilson, JF; Viikari, J; Koenig, W; Blankenberg, S; Newman, AB; Witteman, J; Heiss, G; Duijn, Cv; Scuteri, A; Homuth, G; Mitchell, BD; Gudnason, V; O'Donnell, CJ; CARDIoGRAM Consortium.
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
Nat Genet. 2011; 43(10):940-947 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Petrovic Katja Elisabeth
Schmidt Helena
Schmidt Reinhold
Stögerer Eva Maria
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Number of Figures: 5
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Abstract:
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aging - genetics
Atherosclerosis - genetics
Carotid Intima-Media Thickness -
Cohort Studies -
Coronary Artery Disease - genetics
European Continental Ancestry Group - genetics
Genetic Loci -
Genetic Predisposition to Disease -
Genome, Human -
Genome-Wide Association Study -
Genotype -
Heart - physiopathology
Humans -
Middle Aged -
Phenotype -
Plaque, Atherosclerotic - genetics
Polymorphism, Single Nucleotide -
Risk Factors -

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