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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Trbušić, M; Riederer, M; Vučić, M; Lovričević, I; Krušlin, B; Gauster, M; Mohrenz, S; Berghold, A; Tiran, B; Degoricija, V; Frank, S.
Increased expression of endothelial lipase in symptomatic and unstable carotid plaques.
J Neurol. 2012; 259(3):448-456 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Berghold Andrea
Frank Saša
Gauster Martin
Riederer Monika
Tiran Beate
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Number of Figures: 3
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Abstract:
The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ(2) test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ(2) test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Body Mass Index -
Carotid Arteries - pathology
Carotid Stenosis - complications
Echocardiography, Doppler, Color - methods
Endarterectomy, Carotid - methods
Endothelial Cells - enzymology
Female -
Gene Expression Regulation, Enzymologic - physiology
Humans -
Lipase - metabolism
Magnetic Resonance Angiography -
Male -
Middle Aged -
Receptors, Cell Surface - metabolism
Renin - metabolism
Retrospective Studies -

Find related publications in this database (Keywords)
Endothelial lipase
Carotid artery plaque
High density lipoprotein
Inflammation
Atherosclerosis
Macrophages
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