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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Schmidt, R; Grazer, A; Enzinger, C; Ropele, S; Homayoon, N; Pluta-Fuerst, A; Schwingenschuh, P; Katschnig, P; Cavalieri, M; Schmidt, H; Langkammer, C; Ebner, F; Fazekas, F.
MRI-detected white matter lesions: do they really matter?
J Neural Transm. 2011; 118(5): 673-681.
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Autor/innen der Med Uni Graz:
Cavalieri Margherita
Ebner Franz
Enzinger Christian
Fazekas Franz
Grazer Anja
Homayoon Nina
Katschnig-Winter Petra
Langkammer Christian
Pluta-Fürst Aga
Ropele Stefan
Schmidt Helena
Schmidt Reinhold
Schwingenschuh Petra
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Abstract:
Despite extensive research over the last decades the clinical significance of white matter lesions (WMLs) is still a matter of debate. Here, we review current knowledge of the correlation between WMLs and cognitive functioning as well as their predictive value for future stroke, dementia, and functional decline in activities of daily living. There is clear evidence that age-related WMLs relate to all of these outcomes on a group level, but the inter-individual variability is high. The association between WMLs and clinical phenotypes exists particularly for early confluent to confluent changes, which are ischaemic in aetiology and progress quickly over time. One reason for the variability of the relationship between WMLs and clinic on an individual level is probably the complexity of the association. Numerous factors such as cognitive reserve, concomitant loss of brain volume, and ultrastructural changes have been identified as mediators between white matter damage and clinical findings, and need to be incorporated in the consideration of WMLs as visible markers of these detrimental processes.
Find related publications in this database (using NLM MeSH Indexing)
Activities of Daily Living -
Brain - pathology
Brain Mapping -
Cognition Disorders - diagnosis
Dementia - diagnosis
Humans -
Leukoencephalopathies - complications
Magnetic Resonance Imaging -

Find related publications in this database (Keywords)
Magnetic resonance imaging
MRI
White matter lesions
Cognition
Dementia
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