Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Köttgen, A; Pattaro, C; Böger, CA; Fuchsberger, C; Olden, M; Glazer, NL; Parsa, A; Gao, X; Yang, Q; Smith, AV; O'Connell, JR; Li, M; Schmidt, H; Tanaka, T; Isaacs, A; Ketkar, S; Hwang, SJ; Johnson, AD; Dehghan, A; Teumer, A; Paré, G; Atkinson, EJ; Zeller, T; Lohman, K; Cornelis, MC; Probst-Hensch, NM; Kronenberg, F; Tönjes, A; Hayward, C; Aspelund, T; Eiriksdottir, G; Launer, LJ; Harris, TB; Rampersaud, E; Mitchell, BD; Arking, DE; Boerwinkle, E; Struchalin, M; Cavalieri, M; Singleton, A; Giallauria, F; Metter, J; de Boer, IH; Haritunians, T; Lumley, T; Siscovick, D; Psaty, BM; Zillikens, MC; Oostra, BA; Feitosa, M; Province, M; de Andrade, M; Turner, ST; Schillert, A; Ziegler, A; Wild, PS; Schnabel, RB; Wilde, S; Munzel, TF; Leak, TS; Illig, T; Klopp, N; Meisinger, C; Wichmann, HE; Koenig, W; Zgaga, L; Zemunik, T; Kolcic, I; Minelli, C; Hu, FB; Johansson, A; Igl, W; Zaboli, G; Wild, SH; Wright, AF; Campbell, H; Ellinghaus, D; Schreiber, S; Aulchenko, YS; Felix, JF; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Imboden, M; Nitsch, D; Brandstätter, A; Kollerits, B; Kedenko, L; Mägi, R; Stumvoll, M; Kovacs, P; Boban, M; Campbell, S; Endlich, K; Völzke, H; Kroemer, HK; Nauck, M; Völker, U; Polasek, O; Vitart, V; Badola, S; Parker, AN; Ridker, PM; Kardia, SL; Blankenberg, S; Liu, Y; Curhan, GC; Franke, A; Rochat, T; Paulweber, B; Prokopenko, I; Wang, W; Gudnason, V; Shuldiner, AR; Coresh, J; Schmidt, R; Ferrucci, L; Shlipak, MG; van Duijn, CM; Borecki, I; Krämer, BK; Rudan, I; Gyllensten, U; Wilson, JF; Witteman, JC; Pramstaller, PP; Rettig, R; Hastie, N; Chasman, DI; Kao, WH; Heid, IM; Fox, CS.
New loci associated with kidney function and chronic kidney disease.
Nat Genet. 2010; 42(5): 376-384. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG Google Scholar

 

Autor/innen der Med Uni Graz:
Cavalieri Margherita
Schmidt Helena
Schmidt Reinhold
Altmetrics:

Dimensions Citations:

Plum Analytics:
Number of Figures: 3
| | |
Abstract:
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Find related publications in this database (using NLM MeSH Indexing)
Cohort Studies -
Creatinine - blood
Cystatin C - genetics
Diet -
Europe -
Genetic Markers - genetics
Genome-Wide Association Study -
Glomerular Filtration Rate -
Humans -
Kidney - physiology
Kidney Failure, Chronic - ethnology Kidney Failure, Chronic - genetics
Models, Genetic -
Risk Factors -

© Meduni Graz Impressum