Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Perakis, S; Auer, M; Belic, J; Heitzer, E.
Advances in Circulating Tumor DNA Analysis.
Adv Clin Chem. 2017; 80:73-153
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Auer Martina
Belic Jelena
Heitzer Ellen
Perakis Samantha
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Abstract:
The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might revolutionize cancer care with respect to early detection, identification of minimal residual disease, assessment of treatment response, and monitoring tumor evolution. ctDNA analysis, often referred to as "liquid biopsy" offers what tissue biopsies cannot-a continuous monitoring of tumor-specific changes during the entire course of the disease. Owing to technological improvements, efforts for the establishment of preanalytical and analytical benchmark, and the inclusion of ctDNA analyses in clinical trial, an actual clinical implementation has come within easy reach. In this chapter, recent advances of the analysis of ctDNA are summarized starting from the discovery of cell-free DNA, to methodological approaches and the clinical applicability. © 2017 Elsevier Inc. All rights reserved.

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