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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Ulz, P; Gerger, A; Belic, J; Heitzer, E.
Potentials, challenges and limitations of a molecular characterization of circulating tumor DNA for the management of cancer patients
LABORATORIUMSMEDIZIN. 2016; 40(5): 323-334.
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Autor/innen der Med Uni Graz:
Belic Jelena
Gerger Armin
Heitzer Ellen
Ulz Peter
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Abstract:
A liquid profiling, i.e. the analysis of cell-free circulating tumor DNA (ctDNA), enables a continuous non-invasive monitoring of tumor-specific changes during the entire course of the disease with respect to early detection, identification of minimal residual disease, assessment of treatment response and monitoring tumor evolution. Technological improvements, advances in understanding the nature of ctDNA, the implementation of ctDNA analyses in clinical trials as well as efforts for the establishment of benchmarks, will bring an actual widespread clinic use within reach in the near future. However, despite this progress there are still hurdles that have to be overcome, which are discussed in this review. Moreover, present knowledge and new findings about the biology of ctDNA as well as selected potential clinical applications for metastatic cancer patients are pointed out.

Find related publications in this database (Keywords)
assessment of treatment response
cell-free circulating DNA
ctDNA
identification of actionable targets
monitoring tumor evolution
predictive and prognostic biomarker
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