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SHR Neuro Krebs Kardio Lipid

Saraggi, D; Salmaso, R; Zamuner, C; Munari, G; Lanza, C; Alaibac, MS; Bassetto, F; Rugge, M; Montesco, MC; Cerroni, L; Fassan, M.
Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesions.
J Am Acad Dermatol. 2018; 79(4):728-735
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Cerroni Lorenzo
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Abstract:
ALK receptor tyrosine kinase gene (ALK) rearrangements have been described in spitzoid lesions with a plexiform growth pattern. To investigate the prevalence of ALK alterations in a large series of spitzoid lesions. ALK immunohistochemical and fluorescence in situ hybridization analyses of 78 spitzoid plexiform lesions including 41 Spitz nevi, 29 atypical Spitz tumors (ASTs), and 8 spitzoid melanomas. ALK immunohistochemical staining was observed in 14.6% of Spitz nevi (6 of 41) and 13.8% of ASTs (4 of 29); the spitzoid melanomas were ALK negative. Fluorescence in situ hybridization confirmed ALK translocation in 9 cases and amplification in 1 case. In 2 of the translocated cases it was possible to determine the fusion partner gene (ie, tropomyosin 3 gene [TPM3] or dynactin 1 gene [DCTN1]). Of the 4 cases of AST examined, 2 carried the B-Raf proto-oncogene, serine/threonine kinase gene (BRAF) V600E mutation. The 10 patients had a mean age of 18.7 years (range, 1-39) and a female predominance (female-to-male ratio, 7:3). Seven lesions arose on the extremities; the 2 lesions occurring in infants were located on the face. The lesions' mean diameter was 6.2 mm (range, 3-13), and their mean Breslow thickness was 1.83 mm (range, 0.6-3.6). The results of sentinel node biopsy were negative in 2 ASTs. BRAF status was tested in only 4 of 10 samples because of the limited amount of material. ALK alterations characterize a significant subset of spitzoid lesions. Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
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Adolescent -
Adult -
Anaplastic Lymphoma Kinase - genetics
Child -
Child, Preschool -
Cohort Studies -
Female -
Genetic Predisposition to Disease - epidemiology
Genetic Variation -
Humans -
Immunohistochemistry -
In Situ Hybridization, Fluorescence -
Male -
Mutation -
Neoplasm Invasiveness - pathology
Neoplasm Staging -
Nevus, Epithelioid and Spindle Cell - genetics
Nevus, Epithelioid and Spindle Cell - pathology
Nevus, Epithelioid and Spindle Cell - surgery
Prognosis -
Real-Time Polymerase Chain Reaction - methods
Retrospective Studies -
Sentinel Lymph Node Biopsy -
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Young Adult -

Find related publications in this database (Keywords)
ALK
atypical Spitz tumor
plexiform melanocytic lesions
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