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SHR Neuro Krebs Kardio Lipid

Bhat, VK; Krump, C; Bernhart, E; Becker, JC; Sattler, W; Ghaffari-Tabrizi-Wizsy, N.
A short-term in vivo model for Merkel Cell Carcinoma.
Exp Dermatol. 2018; 27(6):684-687 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Becker Jürgen Christian
Bernhart Eva Maria
Bhat Kumble Vishwanath
Ghaffari Tabrizi-Wizsy Nassim
Krump Corinna
Sattler Wolfgang

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Number of Figures: 2
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In vivo tumor models are essential for studying the biology of cancer, identifying tumor targets and evaluating antitumor drugs. Considering the request for the minimisation of animal experiments and following the "3R"-rule ("replacement," "refinement," "reduction"), it has become crucial to develop alternative experimental models in cancer biology. Several studies have already described the avian chorioallantoic membrane (CAM) model as an alternative to rodents, suitable to investigate growth, progression and metastasis of various types of cancer. In the present work, we grafted three Merkel cell carcinoma (MCC) cell lines onto the avian CAM and monitored tumor growth and development of solid tumor nodules. Morphology of xenograft was characterised histologically and immunohistochemically. Our results demonstrate CAM assay as a useful tool to study MCC pathophysiology. © 2018 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd.

Find related publications in this database (Keywords)
Chorioallantoic membrane assay
MCPyV-LT antigen
Merkel cell carcinoma
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