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SHR Neuro Krebs Kardio Lipid

Santibanez, JF; Obradović, H; Kukolj, T; Krstić, J.
Transforming growth factor-β, matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition.
Dev Dyn. 2018; 247(3):382-395 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Krstic Jelena
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Abstract:
Transforming growth factor-β (TGF-β) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF-β tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF-β activation, thus contributing to tumor malignancy. TGF-β is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-β, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Movement -
Disease Progression -
Epithelial-Mesenchymal Transition -
Extracellular Matrix - metabolism
Humans -
Matrix Metalloproteinases - metabolism
Neoplasms - pathology
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta - physiology
Urokinase-Type Plasminogen Activator - metabolism

Find related publications in this database (Keywords)
EMT
tumor progression
invasion
stroma
extracellular matrix proteinases
metastasis
TGF-beta
MMP
uPA
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