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SHR Neuro Krebs Kardio Lipid

Wolff, I; Scavuzzo, A; Capitanio, U; Klatte, T; Shariat, SF; Wagener, N; Zastrow, S; Borgmann, H; Krabbe, LM; Hutterer, G; May, M; Brookman-May, SD; Collaborative Research On Renal Neoplasms Association (CORONA) and the European Association of Urology (EAU) Young Academic Urologists (YAU) Kidney Cancer Group.
Organ Preservation Is Less Frequently Performed in Women Surgically Treated for Papillary Renal Cell Carcinoma-Results of a Comprehensive Multicenter Study.
Urology. 2017; 109(1):107-114
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Hutterer Georg C.
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Abstract:
To analyze the impact of gender on the clinicopathologic features and survival of patients with surgically treated papillary renal cell carcinoma (papRCC) using a comprehensive international multicenter database. Data of 2325 patients undergoing surgery for unilateral papRCC between 1984 and 2015 in 17 European and North American centers were retrospectively collated. The impact of clinicopathologic features on the likelihood of nephron-sparing surgery (NSS) was evaluated using a multivariable logistic regression model. The influence on cancer-specific mortality (CSM) and other-cause mortality was analyzed by multivariable competing-risk regression models. Finally, subgroup analyses were conducted for organ-confined (n = 2075) and non-organ-confined tumors (n = 250). The median follow-up was 47 months. The study cohort included 1782 (77%) male patients (male-to-female ratio 3.3:1.0). Considering age, symptoms at presentation, performance status, pathologic tumor size, stage, and grade, we observed that there were no significant gender-specific differences. In contrast, female patients underwent NSS significantly less frequently (P <.001). On multivariable analysis, the likelihood of NSS was 72% higher in male patients after adjusting for all relevant cofactors (P <.001). No significant gender-specific differences in terms of CSM and other-cause mortality were demonstrated, but CSM was 59% lower in female patients in the subgroup of organ-confined tumors (P = .001). No impact of gender on survival was found analyzing this large cohort of patients undergoing surgery for papRCC. However, CSM appears to be lower in female patients with organ-confined disease. In this context, it is interesting that the likelihood of NSS seems to be significantly higher in male patients. Copyright © 2017 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - surgery
Female -
Humans -
Kidney Neoplasms - diagnosis
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Male -
Middle Aged -
Nephrectomy - methods
Nephrons -
Organ Sparing Treatments - statistics & numerical data
Retrospective Studies -
Sex Distribution -
Survival Rate -

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