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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Pulewka, K; Wolff, D; Herzberg, PY; Greinix, H; Heussner, P; Mumm, FHA; von Harsdorf, S; Rieger, K; Hemmati, P; Hochhaus, A; Hilgendorf, I.
Physical and psychosocial aspects of adolescent and young adults after allogeneic hematopoietic stem-cell transplantation: results from a prospective multicenter trial.
J Cancer Res Clin Oncol. 2017; 143(8):1613-1619
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Greinix Hildegard

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Plum Analytics:
Allogeneic hematopoietic stem-cell transplantation (alloHSCT) is physically and psychosocially demanding. Among transplant recipients, adolescent and young adults (AYA) represent a special group, as disease occurs early in life, resulting in the prospect of long survival time and high burden of alloHSCT sequelae. However, data focusing on AYA undergoing alloHSCT are rare. Data resulting from a prospective multicenter trial initially focusing on graft-versus-host disease (GvHD) after alloHSCT were reused to analyse the differences between AYA and elderly patients. In total, data of 205 alloHSCT recipients were evaluated. Patients completed the FACT-BMT, HAP, SF-36, 24-AM, LOT-R, BSSS, HADS, and GvHD questionnaires. Median age of AYA and non-AYA patients was 29 and 52 years. Using 24-AM-Test, evaluating personality traits, non-AYA reported to be more conscientious (p = 0.033). However, AYA described higher quality of life regarding physical role functioning (p = 0.001), physical functioning (p = 0.002), bodily pain (p = 0.023), and emotional role function (p = 0.027) in the SF-36. General health perception, vitality, social role functioning, and mental health were comparable among both groups. On HAP scale, AYA reported higher maximum (p = 0.003) and adjusted activity scores (p = 0.002), but showed similar restrictions regarding activity, self-supply, and self-determination. AYA represent a particular group characterized by higher physical well-being and activity scores, and significantly vary from non-AYA patients in psychosocial aspects. Studies covering distinctive features of AYA undergoing alloHSCT are warranted to improve awareness of the special needs of this group.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Age Factors -
Aged -
Female -
Graft vs Host Disease - pathology
Graft vs Host Disease - psychology
Hematologic Neoplasms - epidemiology
Hematologic Neoplasms - pathology
Hematologic Neoplasms - psychology
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - psychology
Humans -
Male -
Middle Aged -
Quality of Life -
Surveys and Questionnaires -
Young Adult -

Find related publications in this database (Keywords)
Adolescents and young adults (AYA)
Stem-cell transplantation
Quality of life
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