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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Dengler, M; Staufer, K; Huber, H; Stauber, R; Bantel, H; Weiss, KH; Starlinger, P; Pock, H; Klöters-Plachky, P; Gotthardt, DN; Rauch, P; Lackner, C; Stift, J; Brostjan, C; Gruenberger, T; Kumada, T; Toyoda, H; Tada, T; Weiss, TS; Trauner, M; Mikulits, W.
Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis.
Oncotarget. 2017; 8(28):46234-46248 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Lackner Karoline
Pock Hannelore
Stauber Rudolf
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Number of Figures: 5
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Abstract:
Patients with chronic liver disease (CLD) and cirrhosis are at high risk for hepatocellular carcinoma (HCC). Current diagnostic tools for HCC detection include imaging techniques and serum biomarkers such as α-fetoprotein (AFP). Yet, these methods are limited in sensitivity and specificity to accurately detect early HCC. Here we focused on the potential of soluble Axl (sAxl) as a biomarker in CLD patients by analyzing serum samples of 1067 patients and healthy controls from centers in Europe and Asia. We show that serum concentrations of sAxl were significantly increased at early (82.57 ng/mL) and later stages of HCC (114.50 ng/mL) as compared to healthy controls (40.15 ng/mL). Notably, no elevated sAxl levels were detected in patients with CLD including chronic viral hepatitis, autoimmune hepatitis, cholestatic liver disease, or non-alcoholic fatty liver disease versus healthy controls. Furthermore, sAxl did not rise in liver adenomas or cholangiocarcinoma (CCA). Yet, patients with advanced fibrosis (F3) or cirrhosis (F4) showed enhanced sAxl concentrations (F3: 54.67 ng/mL; F4: 94.74 ng/mL). Hepatic myofibroblasts exhibited an increased release of sAxl, suggesting that elevated sAxl levels arise from these cells during fibrosis. Receiver operating characteristic curve analysis of sAxl displayed a strongly increased sensitivity and specificity to detect both cirrhosis (80.8%/92.0%) and HCC (83.3%/86.7%) with an area under the curve of 0.935/0.903 as compared to AFP. In conclusion, sAxl shows high diagnostic accuracy at early stage HCC as well as cirrhosis, thereby outperforming AFP. Importantly, sAxl remains normal in most common CLDs, liver adenomas and CCA.
Find related publications in this database (using NLM MeSH Indexing)
Asia -
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - pathology
Chronic Disease -
Early Diagnosis -
Europe -
Female -
Fibrosis -
Gene Expression Regulation, Neoplastic -
Humans -
Liver - pathology
Liver Cirrhosis - diagnosis
Liver Cirrhosis - pathology
Liver Neoplasms - pathology
Male -
Middle Aged -
Myofibroblasts - metabolism
Myofibroblasts - pathology
Proto-Oncogene Proteins - blood
Receptor Protein-Tyrosine Kinases - blood
Risk -
Sensitivity and Specificity -
Up-Regulation -

Find related publications in this database (Keywords)
soluble Axl
biomarker
fibrosis
cirrhosis
hepatocellular carcinoma
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