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Kargl, J; Busch, SE; Yang, GH; Kim, KH; Hanke, ML; Metz, HE; Hubbard, JJ; Lee, SM; Madtes, DK; McIntosh, MW; Houghton, AM.
Neutrophils dominate the immune cell composition in non-small cell lung cancer.
Nat Commun. 2017; 8(5):14381-14381 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Kargl Julia Katharina
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Number of Figures: 6
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Abstract:
The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase clinical trials combining novel immunotherapeutics with immune checkpoint blockade have been initiated. Unfortunately, these trials have been designed without a strong foundational knowledge of the immune landscape present in NSCLC. Here, we use a flow cytometry panel capable of measuring 51 immune cell populations to comprehensively identify the immune cell composition and function in NSCLC. The results show that the immune cell composition is fundamentally different in lung adenocarcinoma as compared with lung squamous cell carcinoma, and that neutrophils are the most prevalent immune cell type. Using T-cell receptor-β sequencing and tumour reactivity assays, we predict that tumour reactive T cells are frequently present in NSCLC. These results should help to guide the design of clinical trials and the direction of future research in this area.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - immunology
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Carcinoma, Non-Small-Cell Lung - immunology
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - therapy
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cell Count -
Flow Cytometry -
Humans -
Immune System - immunology
Immune System - pathology
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Neutrophils - immunology
Neutrophils - pathology
T-Lymphocytes - immunology
T-Lymphocytes - pathology

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