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Dalpiaz, O; Krieger, D; Ehrlich, GC; Pohlmann, K; Stojakovic, T; Pummer, K; Zigeuner, R; Pichler, M; Hutterer, GC.
Validation of the Preoperative Platelet-to-Lymphocyte Ratio as a Prognostic Factor in a European Cohort of Patients with Upper Tract Urothelial Carcinoma.
Urol Int. 2017; 98(3):320-327
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Autor/innen der Med Uni Graz:
Dalpiaz Orietta
Ehrlich Georg
Hutterer Georg C.
Pichler Martin
Pummer Karl
Stojakovic Tatjana
Zigeuner Richard
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Abstract:
This study is aimed at investigating the potential prognostic impact of the preoperatively assessed platelet-to-lymphocyte ratio (PLR) in a European cohort of patients with non-metastatic upper tract urothelial carcinoma (UTUC). Clinicopathological data from 180 consecutive non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic center, were evaluated retrospectively. The preoperative PLR was assessed one day before surgery. Patients were categorized using a PLR cut-off value according to receiver-operating curve analysis. Cancer-specific survival (CSS) and overall survival (OS) were assessed using the Kaplan-Meier method. Additionally, multivariate proportional Cox regression models were applied. In multivariate analyses, age at the date of surgery (<65 vs. ≥65 years, hazard ratio (HR) 1.827, 95% CI 1.051-3.175, p = 0.033), pathologic T-stage (pT1 vs. pT2-4, HR 1.873, 95% CI 1.066-3.292, p = 0.029), and pretreatment PLR (<150.0 vs. ≥150.0, HR 1.782, 95% CI 1.041-3.050, p = 0.035) were independent predictors of OS. Regarding CSS, pathologic T-stage (pT1 vs. pT2-4, HR 2.176, 95% CI 1.062-4.460, p = 0.034) and pretreatment PLR (<150.0 vs. ≥150.0, HR 2.026, 95% CI 1.045-3.930, p = 0.037) were considered independent predictors. In the cohort studied, patients with an elevated (≥150.0) preoperative PLR had a higher cancer-specific mortality and overall mortality after radical surgery for UTUC, compared with those with a low pretreatment PLR. © 2016 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Blood Platelets - cytology
Cell Count -
Europe -
European Continental Ancestry Group -
Female -
Humans -
Kaplan-Meier Estimate -
Lymphocytes - cytology
Male -
Middle Aged -
Multivariate Analysis -
Neoplasm Metastasis -
Preoperative Period -
Prognosis -
Proportional Hazards Models -
ROC Curve -
Retrospective Studies -
Treatment Outcome -
Urologic Neoplasms - surgery
Urothelium - pathology

Find related publications in this database (Keywords)
Platelet-to-lymphocyte ratio
Prognosis
Survival
Upper tract urothelial carcinoma
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