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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Czapiewski, P; Gorczyński, A; Haybaeck, J; Okoń, K; Reszeć, J; Skrzypczak, W; Dzierżanowski, J; Kunc, M; Karczewska, J; Biernat, W.
Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma.
Pol J Pathol. 2016; 67(2):130-135 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Haybäck Johannes

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Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis. No significant correlation in the expression of PAX5 and TTF-1 ( = 0.43; p = 0.18) was observed. ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive. PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Biomarkers, Tumor - analysis
DNA-Binding Proteins - analysis
DNA-Binding Proteins - biosynthesis
Esthesioneuroblastoma, Olfactory - metabolism
Esthesioneuroblastoma, Olfactory - pathology
Female -
Humans -
Immunohistochemistry -
LIM-Homeodomain Proteins - analysis
LIM-Homeodomain Proteins - biosynthesis
Male -
Middle Aged -
Nasal Cavity - pathology
Nose Neoplasms - metabolism
Nose Neoplasms - pathology
PAX5 Transcription Factor - analysis
PAX5 Transcription Factor - biosynthesis
Transcription Factors - analysis
Transcription Factors - biosynthesis
Young Adult -

Find related publications in this database (Keywords)
olfactory neuroblastoma
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