Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Bollen, L; Wibmer, C; Van der Linden, YM; Pondaag, W; Fiocco, M; Peul, WC; Marijnen, CA; Nelissen, RG; Leithner, A; Dijkstra, SP.
Predictive Value of Six Prognostic Scoring Systems for Spinal Bone Metastases: An Analysis Based on 1379 Patients.
Spine (Phila Pa 1976). 2016; 41(3):E155-E162
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Leithner Andreas
Wibmer Christine

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

A retrospective cohort study. The aim of this study was to assess and compare the predictive accuracy of six models designed to estimate survival of patients suffering from spinal bone metastases Just (SBMs). On the basis of the estimated survival of patients with SBM, extent of treatment can be adjusted. To aid clinicians in the difficult task of assessing probability of survival, prognostic scoring systems have been developed by Tomita, Tokuhashi, Van der Linden, Bauer, Rades, and Bollen. All patients who were treated for SBM between 2000 and 2010 were included in this international, multicenter, retrospective study (n = 1379). Medical records were reviewed for all items needed to use the scoring systems. Survival time was calculated as the difference between start of treatment for SBM and date of death. Survival curves were estimated using the Kaplan-Meier method and accuracy was assessed with the c-statistic. Survival rates of the worst prognostic groups were evaluated at 4 months. Median follow-up was 6.7 years [95% confidence interval (95% CI) 5.6-7.7] with a minimum of 2.3 years and a maximum of 12.3 years. The overall median survival was 5.1 months (95% CI 4.6-5.6). The most common primary tumors were breast (n = 388, 28%), lung (n = 318, 23%), and prostate cancer (n = 259, 19%). The Tokuhashi, Bauer, Tomita, and Van der Linden models performed similar with a c-statistic of 0.64 to 0.66 and a 4-month accuracy of 62% to 65%. The Rades model (c-statistic 0.44) and Bollen model (c-statistic 0.70) had a 4-month accuracy of 69% and 75%, respectively. The Bollen model performs better than the other models. However, improvements are still warranted to increase the accuracy. 3.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Cervical Vertebrae -
Cohort Studies -
Female -
Follow-Up Studies -
Humans -
Internationality -
Lumbar Vertebrae -
Male -
Middle Aged -
Predictive Value of Tests -
Prognosis -
Retrospective Studies -
Severity of Illness Index -
Spinal Neoplasms - diagnosis
Spinal Neoplasms - mortality
Spinal Neoplasms - secondary
Survival Rate - trends
Thoracic Vertebrae -

Find related publications in this database (Keywords)
predictive accuracy
scoring system
spinal bone metastases
treatment decision
© Med Uni Graz Impressum