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Shafirstein, G; Battoo, A; Harris, K; Baumann, H; Gollnick, SO; Lindenmann, J; Nwogu, CE.
Photodynamic Therapy of Non-Small Cell Lung Cancer. Narrative Review and Future Directions.
Ann Am Thorac Soc. 2016; 13(2):265-275 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Lindenmann Jörg

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Number of Figures: 4
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Photodynamic therapy (PDT) is an established treatment modality for non-small cell lung cancer. Phototoxicity, the primary adverse event, is expected to be minimized with the introduction of new photosensitizers that have shown promising results in phase I and II clinical studies. Early-stage and superficial endobronchial lesions less than 1 cm in thickness can be effectively treated with external light sources. Thicker lesions and peripheral lesions may be amenable to interstitial PDT, where the light is delivered intratumorally. The addition of PDT to standard-of-care surgery and chemotherapy can improve survival and outcomes in patients with pleural disease. Intraoperative PDT has shown promise in the treatment of non-small cell lung cancer with pleural spread. Recent preclinical and clinical data suggest that PDT can increase antitumor immunity. Crosslinking of signal transducer and activator of transcription-3 molecules is a reliable biomarker to quantify the photoreaction induced by PDT. Randomized studies are required to test the prognosis value of this biomarker, obtain approval for the new photosensitizers, and test the potential efficacy of interstitial and intraoperative PDT in the treatment of patients with non-small cell lung cancer.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Agents - therapeutic use
Carcinoma, Non-Small-Cell Lung - therapy
Combined Modality Therapy -
Humans -
Intraoperative Care - methods
Lung Neoplasms - therapy
Photochemotherapy - methods
Photochemotherapy - trends
Pneumonectomy -
Prognosis -
Radiotherapy -

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