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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Wimmer, T; Srimathveeravalli, G; Silk, M; Monette, S; Gutta, N; Maybody, M; Erinjery, JP; Coleman, JA; Solomon, SB; Sofocleous, CT.
Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.
Technol Cancer Res Treat. 2016; 15(6):749-758 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Wimmer Thomas
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Number of Figures: 6
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Abstract:
To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy. Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared. Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm2), although both exhibited similar shape. Computed tomography (standard: 556 ± 61 mm2, experimental: 515 ± 67 mm2; P = .25) and histology (standard: 313 ± 77 mm2, experimental: 275 ± 75 mm2; P = .29) indicated ablations with experimental probes were not significantly different from the standard. Histopathology indicated similar morphological changes in both groups. Biopsies from the ablation zone yielded at least 1 core with sufficient tissue for analysis (11 of the 20). A combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes. © The Author(s) 2015.
Find related publications in this database (using NLM MeSH Indexing)
Ablation Techniques - instrumentation
Ablation Techniques - methods
Animals -
Biopsy, Needle - instrumentation
Biopsy, Needle - methods
Electroporation - instrumentation
Electroporation - methods
Female -
Kidney - surgery
Needles -
Swine -
Tomography, X-Ray Computed - instrumentation
Tomography, X-Ray Computed - methods

Find related publications in this database (Keywords)
ablation technique
irreversible electroporation
core needle biopsy
computed tomography
kidney
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