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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Partl, R; Fastner, G; Kaiser, J; Kronhuber, E; Cetin-Strohmer, K; Steffal, C; Böhmer-Breitfelder, B; Mayer, J; Avian, A; Berghold, A.
KPS/LDH index: a simple tool for identifying patients with metastatic melanoma who are unlikely to benefit from palliative whole brain radiotherapy.
Support Care Cancer. 2016; 24(2):523-528 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Avian Alexander
Berghold Andrea
Partl Richard
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Abstract:
Low Karnofsky performance status (KPS) and elevated lactate dehydrogenases (LDHs) as a surrogate marker for tumor load and cell turnover may depict patients with a very short life expectancy. To validate this finding and compare it to other indices, namely, the recursive partitioning analysis (RPA) and diagnosis-specific graded prognostic assessment (DS-GPA), a multicenter analysis was undertaken. A retrospective analysis of 234 metastatic melanoma patients uniformly treated with palliative whole brain radiotherapy (WBRT) was done. Univariate and multivariate analyses were used to determine the impact of patient-, tumor-, and treatment-related parameters on overall survival (OS). KPS and LDH emerged as independent factors predicting OS. By combining KPS and LDH values (KPS/LDH index), groups of patients with statistically significant differences in median OS (days; 95 % CI) after onset of WBRT were identified: group 1 (KPS ≥ 70/normal LDH) 234 (96-372), group 2 (KPS ≥ 70/elevated LDH) 112 (69-155), group 3 (KPS <70/normal LDH) 43 (12-74), and group 4 (KPS <70/elevated LDH) 29 (17-41). Between all four groups, statistically significant differences were observed. The RPA and DS-GPA indices failed to distinguish significantly between good and moderate prognosis and were inferior in predicting a very unfavorable prognosis. The parameters KPS and LDH independently impacted on OS. The combination of both (KPS/LDH index) identified patients with a very short life expectancy, who might be better served by recommending best supportive care instead of WBRT. The KPS/LDH index is simple and effective in terms of time and cost as compared to other prognostic indices.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Biomarkers, Tumor - metabolism
Brain - pathology
Brain Neoplasms - prevention & control
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Female -
Humans -
Karnofsky Performance Status -
Lactate Dehydrogenases - metabolism
Male -
Melanoma - pathology
Melanoma - radiotherapy
Middle Aged -
Multivariate Analysis -
Prognosis -
Retrospective Studies -
Tumor Burden -
Young Adult -

Find related publications in this database (Keywords)
Melanoma
LDH
Brain metastasis
WBRT
Prognostic score
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