Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Benesch, M; Kerbl, R; Schwinger, W; Lackner, H; Pfleger, A; Popper, H; Urban, C.
Discrepancy of clinical, radiographic and histopathologic findings in two children with chronic pulmonary graft-versus-host disease after HLA-identical sibling stem cell transplantation.
Bone Marrow Transplant. 1998; 22(8):809-812 (- Case Report) [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Benesch Martin
Kerbl Reinhold
Lackner Herwig
Pfleger Andreas
Popper Helmuth
Schwinger Wolfgang
Urban Ernst-Christian

Dimensions Citations:

Plum Analytics:
We report two children who presented with cough and shortness of breath 7-8 months after a matched sibling stem cell transplant (SCT) for chronic myelogenous leukemia and myelodysplastic syndrome, respectively. Pulmonary function tests (PFTs) revealed severe airways obstruction (AO). However, radiographic investigations showed no serious abnormalities in the early phase and open lung biopsy revealed only mild lymphocytic bronchiolitis and bronchiolitis obliterans consistent with pulmonary graft-versus-host disease (GVHD). Despite administration of bronchodilators and various immunosuppressive agents obstructive lung disease progressed to pulmonary failure in patient 1, whereas stabilization of the clinical course was observed in patient 2. Serial PFTs were the best predictor of the clinical course in contrast to radiographic and histologic findings. It is concluded that PFTs should be performed repeatedly in pediatric patients after allogeneic SCT with the aim of diagnosing GVHD-associated AO in the subclinical phase. Progressive post-transplant AO necessitates prompt initiation of intensive immunosuppressive therapy in order to stop the underlying immunopathologic process even in the absence of severe radiographic and histologic findings.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Chronic Disease -
Female -
Graft vs Host Disease - pathology
Hematopoietic Stem Cell Transplantation - pathology
Histocompatibility Testing - pathology
Humans - pathology
Leukemia, Myeloid, Chronic - therapy
Lung Diseases - pathology
Male - pathology
Myelodysplastic Syndromes - therapy
Transplantation, Homologous - therapy

Find related publications in this database (Keywords)
stem cell transplantation
graft-versus-host disease
airways obstruction
immunosuppressive therapy
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