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Leithner, A; Gapp, M; Leithner, K; Radl, R; Krippl, P; Beham, A; Windhager, R.
Margins in extra-abdominal desmoid tumors: a comparative analysis.
J Surg Oncol. 2004; 86(3):152-156 Doi: 10.1002/jso.20057
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Führende Autor*innen der Med Uni Graz
Leithner Andreas
Windhager Reinhard
Co-Autor*innen der Med Uni Graz
Beham Alfred
Krippl Peter
Leithner Katharina
Radl Roman

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BACKGROUND AND OBJECTIVES: The main treatment of extra-abdominal desmoid tumors remains surgery, but recurrence rates up to 80% are reported. The impact of microscopic surgical margin status according to the Enneking classification system is discussed controversially. METHODS: Therefore, the authors screened the published literature for reliable data on the importance of a wide or radical excision of extra-abdominal desmoid tumors. All studies with more than ten patients, a surgical treatment only, and margin status stated were included. RESULTS: Only 12 out of 49 identified studies fulfilled the inclusion criteria. One hundred fifty-two primary tumors were excised with wide or radical microscopic surgical margins, while in 260 cases a marginal or intralesional excision was performed. In the first group 41 patients (27%) and in the second one 187 patients (72%) developed a recurrence. Therefore, microscopic surgical margin status according to the Enneking classification system is a significant prognostic factor (P < 0.001). CONCLUSIONS: The data of this review underline the strategy of a wide or radical local excision as the treatment of choice. Furthermore, as a large number of studies had to be excluded from this analysis, exact microscopic surgical margin status should be provided in future studies in order to allow comparability. .
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