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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Schneider, J; Ruschhaupt, M; Buness, A; Asslaber, M; Regitnig, P; Zatloukal, K; Schippinger, W; Ploner, F; Poustka, A; Sültmann, H.
Identification and meta-analysis of a small gene expression signature for the diagnosis of estrogen receptor status in invasive ductal breast cancer.
Int J Cancer. 2006; 119(12):2974-2979 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Asslaber Martin
Ploner Ferdinand
Regitnig Peter
Schippinger Walter
Zatloukal Kurt
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Abstract:
In breast cancer, the determination of estrogen receptor (ER) expression is crucial for the decision on therapeutic strategies. Current ER expression analysis is based on immunohistochemical (IHC) staining of ER on formalin fixed tissue sections. However, low levels of ER expression frequently escape detection because of varying sensitivities of routine histopathological laboratories. Moreover, in estimating ER by IHC the receptor protein only is tested instead of the complex underlying ER pathway, which reflects its biological activity. To overcome this limitation, we have used the microarray technology to study 56 samples of invasive ductal carcinoma. We infer a robust and reliable signature of 10 genes, which is associated with ER expression and presumably therapeutically relevant biological processes. In a meta-analysis, the signature was tested on 3 further independent microarray gene expression data sets, covering different laboratories, array platforms, and clinics. The classification based on the signature showed a very low misclassification rate. In summary, the expression of few genes is sufficient to determine ER status. Future decisions on antiestrogen based therapy in breast cancer could be based on this signature rather than on immunostaining alone.
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Adult -
Aged -
Aged, 80 and over -
Breast Neoplasms - genetics
Carcinoma, Ductal, Breast - genetics
Cation Transport Proteins - genetics
Cluster Analysis - genetics
Female - genetics
GATA3 Transcription Factor - genetics
Gene Expression Profiling - genetics
Gene Expression Regulation, Neoplastic - genetics
Hepatocyte Nuclear Factor 3-alpha - genetics
Humans - genetics
Middle Aged - genetics
Neoplasm Proteins - genetics
Oligonucleotide Array Sequence Analysis - methods
Receptors, Estrogen - genetics
Reproducibility of Results - genetics

Find related publications in this database (Keywords)
gene expression profiling
breast cancer
molecular diagnosis and prognosis
estrogen receptor
meta-analysis
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