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SHR Neuro Krebs Kardio Lipid

Petter-Puchner, AH; Sieber, J; Hopf, R; Ohlinger, W; Schuller, M; Redl, H.
NON-activated protein C as post-treatment after spinal cord compression injury in rats.
Acta Neurochir (Wien). 2006; 148(7):765-771
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BACKGROUND: Neuroprotective effects of recombinant human activated Protein C (rhAPC) in models of Spinal Cord Injury (SCI) and ischemic stroke have been reported in rodents. To rule out immunogenicity of rhAPC and to possibly maintain the physiological PC/thrombin balance the use of zymogen PC in SCI might be preferable. Although activation of Protein C (PC) has been demonstrated in rats, the efficacy and drug safety of NON activated PC has not been previously tested in experimental SCI. METHODS: Twelve rats were subjected to 40 g compression of the spinal cord at TH11 for 20 minutes and randomly allocated to either the NON activated PC (25 IU/kg) or the Placebo group (saline).Results. 25 IU treatment yielded improved recovery from SCI compared to placebo and the triple fold dose of PC (75 IU/kg) was subsequently tested to detect treatment associated complications (TAC). Treatment was administered as a single shot via the right vena jugularis forty minutes after onset of compression. The observation period was 5 weeks in 25 IU treated and 1 week in the 75 IU treated rats. Improvement of motor function recovery was measured with behaviour tests and electrophysiology. FINDINGS: Single shot treatment with 25 IU/kg of NON activated PC led to improved recovery in terms of behaviour and electrophysiology. TACs neither occurred in the 25 IU nor in the 75 IU group within one week. CONCLUSION: NON activated PC is a potent and safe drug in experimental SCI and should be considered for treatment in neurotrauma.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Anti-Inflammatory Agents - metabolism
Anticoagulants - metabolism
Disease Models, Animal - metabolism
Dose-Response Relationship, Drug - metabolism
Evoked Potentials, Somatosensory - drug effects
Injections, Intravenous - drug effects
Male - drug effects
Paralysis - drug therapy
Protein C - metabolism
Rats - metabolism
Rats, Sprague-Dawley - metabolism
Recovery of Function - drug effects
Spinal Cord - drug effects
Spinal Cord Injuries - drug therapy
Treatment Outcome - drug therapy

Find related publications in this database (Keywords)
spinal cord injury
zymogen protein C
drug safety
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