Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Peters, G; Gongoll, S; Langner, C; Mengel, M; Piso, P; Klempnauer, J; Rüschoff, J; Kreipe, H; von Wasielewski, R.
IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer.
Virchows Arch. 2003; 443(2):139-145
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Autor/innen der Med Uni Graz:
Langner Cord
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Abstract:
Insulin-like growth factors (IGF-1 and IGF-2) and the IGF-1 membrane receptor (IGF-1R) have been found to play a critical role in the carcinogenesis of several tumors, among them colorectal cancer (CRC). To study the prognostic impact of these molecules, a total number of 713 cases of CRC were examined for the expression of IGF-1, IGF-2, and IGF-1R. The results were correlated with other clinicopathological data and clinical follow-up. IGF-1 expression was noted in 53 (7.5%), IGF-2 in 88 (12.6%), and IGF-1R in 698 (99.6%) of the cases. There were significant associations between the two growth factors ( P<0.00001), between IGF-1 and Ki-67 proliferation activity ( P<0.05), and between IGF-2 and tumor stage ( P<0.005). IGF-2 positivity was significantly correlated to a worse clinical outcome ( P<0.005) only in univariate, but not in multivariate, survival analysis. A similar trend was obtained for patients with IGF-1-positive CRC, but reached statistical significance only in limited tumor stages (pT1/pT2; P<0.01). Although the synchronous expression of IGF-1, IGF-2, and IGF-1R in a subset of CRC is consistent with an auto-/paracrine loop of cancer cell autostimulation, the prognostic effect of IGF-1 and IGF-2 expression seems to be of limited value. However, the identification of IGF-positive CRC might be beneficial for predictive reasons, as new molecular therapeutic approaches are aimed at the IGF system and related pathways.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - metabolism
Adult - metabolism
Aged - metabolism
Colorectal Neoplasms - metabolism
Female - metabolism
Humans - metabolism
Insulin-Like Growth Factor II - metabolism
Intercellular Signaling Peptides and Proteins - metabolism
Male - metabolism
Middle Aged - metabolism
Prognosis - metabolism
Receptor, IGF Type 1 - metabolism
Survival Analysis - metabolism
Survival Rate - metabolism
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Find related publications in this database (Keywords)
insulin-like growth factors
IGF-1 receptor
colon
cancer
clinical correlation
prognosis
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