Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Haemmerle, G; Lass, A; Zimmermann, R; Gorkiewicz, G; Meyer, C; Rozman, J; Heldmaier, G; Maier, R; Theussl, C; Eder, S; Kratky, D; Wagner, EF; Klingenspor, M; Hoefler, G; Zechner, R.
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.
SCIENCE. 2006; 312: 734-737. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Gorkiewicz Gregor
Hoefler Gerald
Kratky Dagmar
Maier Robert
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Abstract:
Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids (FFAs) from stored fat requires the enzymatic activity of lipases. We showed that genetic inactivation of adipose triglyceride lipase (ATGL) in mice increases adipose mass and leads to triacylglycerol deposition in multiple tissues. ATGL-deficient mice accumulated large amounts of lipid in the heart, causing cardiac dysfunction and premature death. Defective cold adaptation indicated that the enzyme provides FFAs to fuel thermogenesis. The reduced availability of ATGL-derived FFAs leads to increased glucose use, increased glucose tolerance, and increased insulin sensitivity. These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
Find related publications in this database (using NLM MeSH Indexing)
Adipocytes - cytology
Adipose Tissue - anatomy and histology
Animals - anatomy and histology
Blood Glucose - metabolism
Brown Fat - enzymology
Carboxylic Ester Hydrolases - deficiency
Cell Size - deficiency
Energy Metabolism - deficiency
Fatty Acids, Nonesterified - blood
Female - blood
Heart Failure, Congestive - pathology
Homeostasis - pathology
Insulin - blood
Isoproterenol - pharmacology
Kidney - metabolism
Lipase - deficiency
Lipids - blood
Lipolysis - drug effects
Male - drug effects
Mice - drug effects
Myocardium - metabolism
Myocytes, Cardiac - cytology
Oxygen Consumption - cytology
Research Support, Non-U.S. Gov't - cytology
Testis - metabolism
Thermogenesis - metabolism
Triglycerides - metabolism
Ventricular Dysfunction, Left - physiopathology

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