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Gewählte Publikation:

Jäeger, G; Neumeister, P; Brezinschek, R; Höfler, G; Quehenberger, F; Linkesch, W; Sill, H.
Rituximab (anti-CD20 monoclonal antibody) as consolidation of first-line CHOP chemotherapy in patients with follicular lymphoma: a phase II study.
EUR J HAEMATOL 2002 69: 21-26.
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Autor/innen der Med Uni Graz:
Hoefler Gerald
Jäger Gerald
Linkesch Werner
Neumeister Peter
Quehenberger Franz
Sill Heinz
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Abstract:
Advanced stages of follicular lymphoma are deemed incurable by conventional approaches. Immunotherapy with the humanised monoclonal anti-CD20 antibody rituximab represents a new therapeutic option. The aim of our study was to determine the effectiveness and safety of rituximab in the consolidation setting of first-line treated patients with follicular lymphomas. Thus the goal was first to reduce tumour burden using the CHOP regimen as induction treatment followed by consolidation with rituximab administered on a standard 4 wk schedule at a dosage of 375 mg m-2 body surface area. Between August 1998 and April 2001, 41 patients were enrolled in the study. All patients were evaluable with regard to tumour response and toxicity. The overall remission rate in the intent-to-treat analysis was 100%. On subgroup analysis, 20 [83% (95% CI: 63-95%)] of the 24 patients with grade 1 or 2 histology entered complete remission (CR), in 10 cases (42%) after additional rituximab therapy. Rituximab thus led to CR in 10/14 patients [71% (95% CI: 42-92%)] who had merely achieved partial remission (PR) with CHOP. Of 16 evaluable patients with grade 3 histology (excluding one patient achieving CR on CHOP who refused further treatment with rituximab), 15 [94% (95% CI: 63-97%)] achieved CR, 13 (81%) of these while still receiving CHOP. Two of the three patients achieving only PR on CHOP entered CR following rituximab. Thirty-four patients (83%) continued to be in remission during a median follow-up period of 24.3 (9-40) months. Our data suggest that the use of rituximab for consolidation after CHOP may improve CHOP-induced remission and thus increase the CR rate. Furthermore, it was accompanied by a reduced rate of infusion-related side-effects.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antibodies, Monoclonal - administration and dosage
Antineoplastic Combined Chemotherapy Protocols - administration and dosage
Cyclophosphamide - administration and dosage
Disease-Free Survival - administration and dosage
Doxorubicin - administration and dosage
Female - administration and dosage
Follow-Up Studies - administration and dosage
Humans - administration and dosage
Immunotherapy - administration and dosage
Lymphoma, Follicular - drug therapy
Male - drug therapy
Middle Aged - drug therapy
Prednisone - administration and dosage
Remission Induction - administration and dosage
Vincristine - administration and dosage

Find related publications in this database (Keywords)
follicular lymphoma
CHOP
rituximab
consolidation therapy
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