Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Basten, O; Bandorski, D; Langner, C.
Hemangiosarcoma of the liver with unusual expression of neuron-specific enolase (NSE)
Z Gastroenterol. 2002; 40(8):577-580 (- Case Report)
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Autor/innen der Med Uni Graz:
Langner Cord
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Abstract:
A 68-year-old male patient presented with unspecific decline of general health, multiple tumours in the liver discovered by ultrasound examination and a focus suggestive of tumour on chest x-ray. He was hospitalised because of suspected metastatic lung carcinoma. Laboratory analysis revealed a distinct elevation of serum neuron-specific enolase (NSE, 26,1 micro g/l). A CT scan of the abdomen confirmed the presence of multiple tumour foci in both hepatic lobes, while the lung, however, was found to be free of tumour on CT-examination. Bronchoscopy, gastroduodenoscopy and colonoscopy were unremarkable. Subsequently, an ultrasound guided fine-needle biopsy of the liver was performed. Histological examination disclosed hemangiosarcoma with unusual, though unequivocal expression of NSE in tumour cells. As even follow-up examinations were unable to trace out any extrahepatic primary tumour, the hemangiosarcoma was concluded to be of hepatic origin. The patient succumbed to his disease 6 months later, an autopsy was not performed. This case report of a NSE-producing primary hemangiosarcoma of the liver clearly outlines that a histological confirmation of an allegedly clear clinical diagnosis should always be performed because malignant tumours are capable of (co-)expressing so called tumour markers independently of their histogenesis.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Biopsy -
Diagnosis, Differential -
Fatal Outcome -
Follow-Up Studies -
Hemangiosarcoma - pathology
Humans - pathology
Liver - pathology
Liver Neoplasms - pathology
Male - pathology
Phosphopyruvate Hydratase - analysis
Tumor Markers, Biological - analysis

Find related publications in this database (Keywords)
hemangiosarcoma
liver
tumour markers
neuron-specific enolase
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