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Langner, C; Rupar, G; Leibl, S; Hutterer, G; Chromecki, T; Hoefler, G; Rehak, P; Zigeuner, R.
Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression.
Virchows Arch. 2006; 448(3):325-330
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Autor/innen der Med Uni Graz:
Chromecki Thomas
Hoefler Gerald
Hutterer Georg C.
Langner Cord
Leibl Sebastian
Rehak Peter
Zigeuner Richard
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Abstract:
Alpha-methylacyl-CoA racemase (AMACR/P504S) is a useful biomarker of prostate cancer. We evaluated the expression of AMACR in upper urinary tract urothelial carcinomas with respect to associations with tumour stage, grade and metastasis-free survival. A total of 268 tumours were investigated immunohistochemically using a tissue microarray technique. AMACR expression was noted in 127 of 261 (48.7%) evaluated tumours and was associated with high tumour stage [58 of 139 (41.7%) pTa/pT1 vs. 69 of 122 (56.6%) pT2-pT4, P=0.019] and high tumour grade [44 of 137 (32.1%) low vs. 83 of 124 (66.9%) high grade, P<0.001]. In addition, AMACR expression was associated with the presence of tumour necrosis (P<0.001) and marked stromal desmoplasia (P=0.0026). This correlation indicates that increased AMACR expression might be related to hypoxia-induced changes in cancer cell metabolism, such as increased dependence on fatty acid oxidation for energy generation. Progressive disease was observed in 73 of 183 (39.9%) patients with solitary invasive carcinomas and was associated with AMACR expression (P=0.017). Multivariate analysis, however, proved only pT-stage >1 (P<0.001) and high tumour grade (P<0.001) to be independent predictors of patient outcome. In conclusion, AMACR expression correlated with advanced tumour stage and grade and may serve as an additional prognostic indicator in upper urinary tract urothelial cancer.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Carcinoma, Transitional Cell - enzymology Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology
Disease-Free Survival -
Female -
Humans -
Kidney Neoplasms - enzymology Kidney Neoplasms - mortality Kidney Neoplasms - pathology
Male -
Middle Aged -
Proportional Hazards Models -
Racemases and Epimerases - metabolism
Survival Rate -
Tumor Markers, Biological - metabolism
Ureteral Neoplasms - enzymology Ureteral Neoplasms - mortality Ureteral Neoplasms - pathology

Find related publications in this database (Keywords)
urothelial carcinoma
transitional cell carcinoma
upper urinary tract
alpha-methylacyl-CoA racemase (AMACR)
prognosis
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