Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Langner, C; Homayounfar, K; Ruten, B; Fass, J; Rüschoff, J.
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver
Pathologe. 2001; 22(6):417-423 (- Case Report)
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Autor/innen der Med Uni Graz:
Langner Cord
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Abstract:
The simultaneous occurrence of different hepatic tumors is rare. We present for the first time a concomitant manifestation of an angiomyolipoma, a focal nodular hyperplasia, a bile duct adenoma, and a cavernous hemangioma in a 63-year-old female patient. The largest of the tumors, preoperatively suspected to be hepatocellular carcinoma, was an angiomyolipoma with monotypic epithelioid histology and positive immunoreactivity for HMB-45, actin, desmin, and pancytokeratin. The significance of immunohistochemistry for the differential diagnosis of hepatic neoplasms is emphasized. Finally, a review of the literature with special regard to etiology and pathogenesis of neoplastic liver disease is given, leading to the assumption that the association of four different benign intrahepatic tumors is rather more fortuitous than pathogenetically related, despite the putative similar pathogenesis of focal nodular hyperplasia and hemangioma.
Find related publications in this database (using NLM MeSH Indexing)
Adenoma, Bile Duct - pathology
Bile Duct Neoplasms - pathology
Bile Ducts, Intrahepatic - pathology
Cholangiocarcinoma - pathology
Female - pathology
Focal Nodular Hyperplasia - pathology
Hemangioma - pathology
Humans - pathology
Liver - pathology
Middle Aged - pathology
Neoplasms, Multiple Primary - pathology
Tomography, X-Ray Computed - pathology
Tumor Markers, Biological - analysis

Find related publications in this database (Keywords)
angiomyolipoma
focal nodular hyperplasia
simultaneous occurrence
multiple liver tumors
etiology and pathogenesis
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