Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Jatzko, G; Siebert, F; Wolf, B; Karner-Hanusch, J; Kleinert, R; Denk, H.
Combined restorative proctocolectomy and pancreaticoduodenectomy for familial adenomatous polyposis.
Z Gastroenterol. 1999; 37(11):1109-1113 (- Case Report)
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Autor/innen der Med Uni Graz:
Denk Helmut
Kleinert Reinhold

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Plum Analytics:
This is a case report on FAP in a 41-year-old woman in which preoperative examination showed a giant tubulovillous adenoma of the descending duodenum surrounding the papilla of Vater, in addition to pancolon adenomatous polyposis, and isolated adenomas in the gastric antrum and corpus. As it was impossible to remove the giant villous adenoma in the duodenum endoscopically, prophylactic surgical treatment was chosen consisting of restorative proctocolectomy and additional pancreaticoduodenectomy. Flat tubulovillous adenomas in the gastric corpus were successfully removed by total snare biopsies before operation. FAP coli patients treated by prophylactic surgery are now known to be at risk of developing adenomas anywhere in the intestine and many affected patients later die from upper gastrointestinal tumors. In this single case report, the simultaneous occurrence of FAP coli and giant villous adenoma of the duodenum indicates the frequent outcome of this genetic alteration requiring lifelong surveillance. This rare case report includes a short survey of the relevant literature.
Find related publications in this database (using NLM MeSH Indexing)
Adenomatous Polyposis Coli - diagnosis
Adult - diagnosis
Biopsy - diagnosis
Combined Modality Therapy - diagnosis
DNA - genetics
Duodenum - pathology
Female - pathology
Gastric Mucosa - pathology
Humans - pathology
Intestinal Mucosa - pathology
Pancreaticoduodenectomy - methods
Polymerase Chain Reaction - methods
Proctocolectomy, Restorative - methods

Find related publications in this database (Keywords)
familial adenomatous polyposis (FAP)
giant villous adenoma of the duodenum
restorative proctocolectomy
simultaneous pancreaticoduodenectomy
prophylactic surgery
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