Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

Olipitz, W; Beham-Schmid, C; Aigner, R; Raith, J; Linkesch, W; Sill, H.
Acute myelofibrosis: multifocal bone marrow infiltration detected by scintigraphy and magnetic resonance imaging.
ANN HEMATOL 2000 79: 275-278. (- Case Report)
Web of Science PubMed FullText FullText_MUG Google Scholar


Autor/innen der Med Uni Graz:
Aigner Reingard
Beham-Schmid Christine
Linkesch Werner
Olipitz Werner
Raith Johann
Sill Heinz

Dimensions Citations:

Plum Analytics:
Acute myelofibrosis is a rare, malignant hematological disorder of unknown etiology with an inevitably fatal outcome. Here we present the study of a 63-year-old Caucasian man with acute onset of pancytopenia. Repeated bone marrow biopsies showed dense fibrosis and hypoplastic hematopoiesis raising various differential diagnoses of malignant and nonmalignant conditions. Bone marrow scintigraphy and magnetic resonance imaging (MRI) showed areas suggesting neoplastic infiltration, mainly in both femurs and tibias. Histological examination of a surgical biopsy of the left tibia revealed acute megakaryoblastic leukemia. As the patient refused polychemotherapy, therapy with interferon gamma was initiated but discontinued prematurely because of intolerable side effects. The presented case therefore suggests that the combination of bone marrow scintigraphy and MRI is a valuable diagnostic tool in patients presenting with myelofibrosis of unknown origin.
Find related publications in this database (using NLM MeSH Indexing)
Acute Disease -
Antineoplastic Agents - therapeutic use
Bone Marrow - pathology
Humans - pathology
Interferon Type II - therapeutic use
Magnetic Resonance Imaging - therapeutic use
Male - therapeutic use
Middle Aged - therapeutic use
Myelofibrosis - diagnosis
Platelet-Derived Growth Factor - antagonists and inhibitors
Research Support, Non-U.S. Gov't - antagonists and inhibitors
Tibia - pathology
Transforming Growth Factor beta - antagonists and inhibitors

Find related publications in this database (Keywords)
acute myelofibrosis
acute megakaryoblastic leukemia
magnetic resonance imaging
interferon gamma
© Meduni Graz Impressum