Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Reich, O; Regauer, S; Urdl, W; Lahousen, M; Winter, R.
Expression of oestrogen and progesterone receptors in low-grade endometrial stromal sarcomas.
Br J Cancer. 2000; 82(5):1030-1034 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Lahousen Manfred
Regauer Sigrid
Reich Olaf
Urdl Wolfgang
Winter Raimund
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Abstract:
We analysed oestrogen receptor (ER) and progesterone receptor (PR) expression in a retrospective series of 21 low-grade endometrial stromal sarcomas (LGSSs). Archival formalin-fixed and paraffin-embedded material was analysed by immunohistochemistry. ER and PR were measured with monoclonal antibodies and the peroxidase-antiperoxidase method and a score was calculated as for breast carcinoma based on both the percentage of positive tumour cell nuclei and the staining intensity. ER were seen in 15 (71%) and PR in 20 (95%) of tumours respectively. ER expression was scored as high in three (14%), moderate in four (19%), and low in eight (38%) tumours. Six (29%) tumours did not stain for ER and all of these were positive for PR. PR expression was scored as high in eight (38%), moderate in ten (47%) and weak in two (10%) LGSSs. Only one (5%) LGSS did not stain for PR (this tumour was positive for ER). ER and PR expression in LGSS is heterogeneous. This may have implications for hormone therapy in the management of these tumours. These results suggest that ER and PR should be routinely quantified in LGSSs by immunohistochemical methods.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Endometrial Neoplasms - metabolism
Female - metabolism
Humans - metabolism
Middle Aged - metabolism
Receptors, Estrogen - biosynthesis
Receptors, Progesterone - biosynthesis
Retrospective Studies - biosynthesis
Sarcoma, Endometrial Stromal - metabolism

Find related publications in this database (Keywords)
uterus
cancer
endometrium
stromal sarcoma
oestrogen receptor
progesterone receptor
immunohistochemistry
treatment
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