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SHR Neuro Krebs Kardio Lipid

Leithner, A; Gapp, M; Radl, R; Pascher, A; Krippl, P; Leithner, K; Windhager, R; Beham, A.
Immunohistochemical analysis of desmoid tumours.
J CLIN PATHOL. 2005; 58(11): 1152-1156. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Beham Alfred
Krippl Peter
Leithner Andreas
Leithner Katharina
Pascher Arnulf
Radl Roman
Windhager Reinhard

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Number of Figures: 2
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Background/AIMS: Although the standard treatment for desmoid tumours is complete surgical resection with wide margins, the optimal adjuvant treatment for recurrent or inoperable disease is unclear, often being based on sporadic immunohistochemical reports with a low number of cases. Therefore, a large immunohistochemical study was performed, to provide a theoretical basis for adjuvant treatment regimens.METHODS: One hundred and sixteen tissue samples from 80 patients (49 female, 31 male; mean age, 34 years; range, 0-83) with desmoid tumours (46 extra-abdominal, 21 abdominal, 13 intra-abdominal) were tested for oestrogen receptors alpha and beta, progesterone and androgen receptors, and somatostatin, in addition to HER2, cathepsin D, Ki-67, and c-KIT by immunohistochemistry.RESULTS: All samples were negative for oestrogen receptor alpha, HER2, and the progesterone receptor. Positive staining for the androgen receptor was found in six extra-abdominal cases. Staining for oestrogen receptor beta was positive in four extra-abdominal, two abdominal, and one intra-abdominal case. Staining for somatostatin was positive in six extra-abdominal, two abdominal, and one intra-abdominal case, and staining for cathepsin D was positive in all cases. Positive staining for Ki-67 was found in 14 extra-abdominal, three abdominal, and three intra-abdominal cases. C-KIT was detectable in one abdominal case only.CONCLUSIONS: The data from this immunohistochemical study show that the published effects of antioestrogens and imatinib mesylate in the treatment of aggressive fibromatoses may not be attributable to oestrogen receptor alpha or c-KIT expression.
Find related publications in this database (using NLM MeSH Indexing)
Abdominal Neoplasms - chemistry
Adolescent - chemistry
Adult - chemistry
Aged - chemistry
Aged, 80 and over - chemistry
Cathepsin D - analysis
Chemotherapy, Adjuvant - analysis
Child - analysis
Child, Preschool - analysis
Female - analysis
Fibromatosis, Aggressive - drug therapy
Humans - drug therapy
Infant - drug therapy
Infant, Newborn - drug therapy
Ki-67 Antigen - analysis
Male - analysis
Middle Aged - analysis
Neoplasm Proteins - analysis
Proto-Oncogene Proteins c-kit - analysis
Receptors, Androgen - analysis
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Soft Tissue Neoplasms - chemistry
Somatostatin - analysis
Tumor Markers, Biological - analysis

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