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SHR Neuro Krebs Kardio Lipid

Deutschmann, A; Mache, CJ; Bodo, K; Zebedin, D; Ring, E.
Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor-alpha blockage.
PEDIATRICS. 2005; 116(5): 1231-1233. (- Case Report) [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Bodo Koppany
Deutschmann Andrea
Mache Christoph
Ring Ekkehard
Zebedin Doris
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Abstract:
We describe the case of an 18-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) over a period of 10 years. She had suffered predominantly from very painful recurrent swelling of her cheeks. Various therapeutic regimens including nonsteroidal antiinflammatory drugs and steroids had shown only a partial or temporary response. Because tumor necrosis factor-alpha-blocking agents have been successfully applied in Crohn's-associated CRMO and the related SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, tumor necrosis factor-alpha-blocking therapy with infliximab was initiated. Thereafter, apart from 1 mild episode, no additional recurrences were observed during 21 months of follow-up. Infliximab was well tolerated, and steroids were tapered off. Our observation indicates that infliximab may be an effective therapeutic option in CRMO.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Antibodies, Monoclonal - therapeutic use
Biopsy -
Chronic Disease -
Female -
Humans -
Osteomyelitis - diagnosis Osteomyelitis - drug therapy Osteomyelitis - pathology
Recurrence -
Skull - pathology
Tumor Necrosis Factor-alpha - antagonists and inhibitors

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