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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fajardo, Martinez, V; Zhang, D; Paiola, S; Mok, T; Cambou, MC; Kerin, T; Rao, R; Brasil, P; Ferreira, F; Fuller, T; Bhattacharya, D; Foo, SS; Chen, W; Jung, J; Einspieler, C; Marschik, PB; Nielsen-Saines, K.
Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study.
BMJ Open. 2023; 13(1): e069194 Doi: 10.1136/bmjopen-2022-069194 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Marschik Dajie
Co-Autor*innen der Med Uni Graz
Einspieler Christa
Marschik Peter

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OBJECTIVE: To evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19. DESIGN: Longitudinal cohort study. SETTING: Hospital-based study in Los Angeles, USA and Rio de Janeiro, Brazil between March 2020 and December 2021. PARTICIPANTS: Infants born to mothers with COVID-19 during pregnancy and prepandemic control infants from the Graz University Database. INTERVENTIONS: General movement assessment (GMA) videos between 3 and 5 months post-term age were collected and clinical assessments/developmental milestones evaluated at 6-8 months of age. Cases were matched by gestational age, gender and post-term age to prepandemic neurotypical unexposed controls from the database. MAIN OUTCOME MEASURES: Motor Optimality Scores Revised (MOS-R) at 3-5 months. Presence of developmental delay (DD) at 6-8 months. RESULTS: 239 infants were enrolled; 124 cases (83 in the USA/41 in Brazil) and 115 controls. GMA was assessed in 115 cases and 115 controls; 25% were preterm. Median MOS-R in cases was 23 (IQR 21-24, range 9-28) vs 25 (IQR 24-26, range 20-28) in controls, p<0.001. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6-8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. The timing of maternal infection in pregnancy (first, second or third trimester) or COVID-19 disease severity (NIH categories asymptomatic, mild/moderate or severe/critical) was not associated with suboptimal MOS-R or DD. Maternal fever in pregnancy was associated with DD (OR 3.7; 95% CI 1.12 to 12.60) but not suboptimal MOS-R (OR 0.25; 95% CI 0.04 to 0.96). CONCLUSIONS: Compared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development.
Find related publications in this database (using NLM MeSH Indexing)
Infant, Newborn - administration & dosage
Infant - administration & dosage
Humans - administration & dosage
Pregnancy - administration & dosage
Female - administration & dosage
Cohort Studies - administration & dosage
Longitudinal Studies - administration & dosage
Brazil - administration & dosage
COVID-19 - administration & dosage
Pregnancy Complications, Infectious - administration & dosage

Find related publications in this database (Keywords)
Paediatric neurology
Paediatric infectious disease & immunisation
Maternal medicine
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