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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hegen, H; Arrambide, G; Gnanapavan, S; Kaplan, B; Khalil, M; Saadeh, R; Teunissen, C; Tumani, H; Villar, LM; Willrich, MAV; Zetterberg, H; Deisenhammer, F.
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement.
Mult Scler. 2023; 29(2):182-195 Doi: 10.1177/13524585221134217 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Khalil Michael

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Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. The gold standard to determine intrathecal IgG synthesis is the detection of CSF-restricted oligoclonal bands (OCBs). However, advances in laboratory methods brought up κ-free light chains (FLCs) as a new biomarker, which are produced in excess over intact immunoglobulins and accumulate in CSF in the case of central nervous system-derived inflammation. Overwhelming evidence showed a high diagnostic accuracy of intrathecal κ-FLC synthesis in MS with sensitivity and specificity of approximately 90% similar to OCB. κ-FLCs have advantages as its detection is fast, easy, cost-effective, reliable, rater-independent and returning quantitative results which might also improve the value of predicting MS disease activity. An international panel of experts in MS and CSF diagnostics developed a consensus of all participants. Six recommendations are given for establishing standard CSF evaluation in patients suspected of having MS. The panel recommended to include intrathecal κ-FLC synthesis in the next revision of MS diagnostic criteria as an additional tool to measure intrathecal immunoglobulin synthesis.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Multiple Sclerosis - diagnosis, cerebrospinal fluid
Immunoglobulin kappa-Chains - cerebrospinal fluid
Immunoglobulin G - cerebrospinal fluid
Biomarkers - cerebrospinal fluid
Sensitivity and Specificity - administration & dosage
Oligoclonal Bands - cerebrospinal fluid

Find related publications in this database (Keywords)
Cerebrospinal fluid
kappa-free light chains
multiple sclerosis
clinically isolated syndrome
disease activity
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