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Almer, G; Opriessnig, P; Wolinski, H; Sommer, G; Diwoky, C; Lechleitner, M; Kolb, D; Bubalo, V; Brunner, MS; Schwarz, AN; Leitinger, G; Schoiswohl, G; Marsche, G; Niedrist, T; Schauer, S; Oswald, W; Groselj-Strele, A; Paar, M; Cvirn, G; Hoefler, G; Rechberger, GN; Herrmann, M; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Hörl, G; Tehlivets, O.
Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta.
Biomed Pharmacother. 2022; 154:113640 Doi: 10.1016/j.biopha.2022.113640
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Führende Autor*innen der Med Uni Graz
Almer Gunter
Hörl Gerd
Co-Autor*innen der Med Uni Graz
Bubalo Vladimir
Cvirn Gerhard
Diwoky Clemens
Frank Sasa
Groselj-Strele Andrea
Herrmann Markus
Höfler Gerald
Kolb Dagmar
Kratky Dagmar
Lechleitner Margarete
Leitinger Gerd
Mangge Harald
Marsche Gunther
Niedrist Tobias
Opriessnig Peter
Oswald Wolfgang Kurt
Paar Margret
Schauer Silvia
Sommer Gerhard
Tehlivets Oksana
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Abstract:
Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma homocysteine is an independent risk factor for atherosclerosis and is strongly linked to cardiovascular mortality. However, the role of homocysteine in atherosclerosis is still insufficiently understood. Previous research in this area has been also hampered by the lack of reproducible in vivo models of atherosclerosis that resemble the human situation. Here, we have developed and applied an automated system for vessel wall injury that leads to more homogenous damage and more pronounced atherosclerotic plaque development, even at low balloon pressure. Our automated system helped to glean vital details of cholesterol-independent changes in the aortic wall of balloon-injured rabbits. We show that deficiency of B vitamins, which are required for homocysteine degradation, leads to atherogenic transformation of the aorta resulting in accumulation of macrophages and lipids, impairment of its biomechanical properties and disorganization of aortic collagen/elastin in the absence of hypercholesterolemia. A combination of B vitamin deficiency and hypercholesterolemia leads to thickening of the aorta, decreased aortic water diffusion, increased LDL-cholesterol and impaired vascular reactivity compared to any single condition. Our findings suggest that deficiency of B vitamins leads to atherogenic transformation of the aorta even in the absence of hypercholesterolemia and aggravates atherosclerosis development in its presence.
Find related publications in this database (using NLM MeSH Indexing)
Animals - administration & dosage
Aorta - metabolism
Atherosclerosis - metabolism
Cholesterol - administration & dosage
Diet, Atherogenic - administration & dosage
Homocysteine - metabolism
Humans - administration & dosage
Hypercholesterolemia - metabolism
Hyperlipidemias - metabolism
Rabbits - administration & dosage
Vitamin B Complex - administration & dosage

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